Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells

BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Growing evidence indicates that tumor-initiating cells (TICs) are responsible for tumor growth and progression. Conventional chemotherapeutics do not sufficiently eliminate TICs, leading to tumor relapse. We ai...

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Vydáno v:Ann Surg Oncol
Hlavní autoři: Malkomes, Patrizia, Lunger, Ilaria, Luetticke, Alexander, Oppermann, Elsie, Haetscher, Nadine, Serve, Hubert, Holzer, Katharina, Bechstein, Wolf Otto, Rieger, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2016
Témata:
Colorectal Cancer
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972858/
https://ncbi.nlm.nih.gov/pubmed/27059026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-016-5218-z
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