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A stem cell model of the motor circuit uncouples motor neuron death from hyperexcitability induced by SMN deficiency
In spinal muscular atrophy—a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein—sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss. Whether central synaptic dysfunction and MN hyperexcitability are cell auton...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4972669/ https://ncbi.nlm.nih.gov/pubmed/27452470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.087 |
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