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A stem cell model of the motor circuit uncouples motor neuron death from hyperexcitability induced by SMN deficiency
In spinal muscular atrophy—a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein—sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss. Whether central synaptic dysfunction and MN hyperexcitability are cell auton...
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| Veröffentlicht in: | Cell Rep |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4972669/ https://ncbi.nlm.nih.gov/pubmed/27452470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.087 |
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