A SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function

Spinal muscular atrophy (SMA) is a motor neuron disease caused by deficiency of the ubiquitous survival motor neuron (SMN) protein. To define the mechanisms of selective neuronal dysfunction in SMA, we investigated the role of SMN-dependent U12 splicing events in the regulation of motor circuit acti...

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Main Authors: Lotti, Francesco, Imlach, Wendy L., Saieva, Luciano, Beck, Erin S., Hao, Le T., Li, Darrick K., Jiao, Wei, Mentis, George Z., Beattie, Christine E., McCabe, Brian D., Pellizzoni, Livio
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474596/
https://ncbi.nlm.nih.gov/pubmed/23063131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.012
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