Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

PPARγ has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione drugs. Here we show that apigenin binds and activates PPARγ by acting as a modulator. Activation of PPARγ by apigenin blocks p65 translocation into nuclei through inhibition of p65...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Feng, Xiujing, Weng, Dan, Zhou, Feifei, Owen, Young D., Qin, Haohan, Zhao, Jingfa, WenYu, Huang, Yahong, Chen, Jiajia, Fu, Haijian, Yang, Nanfei, Chen, Dianhua, Li, Jianxin, Tan, Renxiang, Shen, Pingping
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972579/
https://ncbi.nlm.nih.gov/pubmed/27374313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.06.017
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