Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for cytotoxicity against NSCLC cells and identified several CAD antihistamines as inducers of lysosomal cell death. We then p...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Ellegaard, Anne-Marie, Dehlendorff, Christian, Vind, Anna C., Anand, Atul, Cederkvist, Luise, Petersen, Nikolaj H.T., Nylandsted, Jesper, Stenvang, Jan, Mellemgaard, Anders, Østerlind, Kell, Friis, Søren, Jäättelä, Marja
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972561/
https://ncbi.nlm.nih.gov/pubmed/27333030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.06.013
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