Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension

BACKGROUND AND AIMS: Infants with Down syndrome (DS) or Trisomy 21, are at high risk for developing pulmonary arterial hypertension (PAH), but mechanisms that increase susceptibility are poorly understood. Laboratory studies have shown that early disruption of angiogenesis during development impairs...

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Udgivet i:PLoS One
Main Authors: Galambos, Csaba, Minic, Angela D., Bush, Douglas, Nguyen, Dominique, Dodson, Blair, Seedorf, Gregory, Abman, Steven H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972384/
https://ncbi.nlm.nih.gov/pubmed/27487163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159005
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