Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension

BACKGROUND AND AIMS: Infants with Down syndrome (DS) or Trisomy 21, are at high risk for developing pulmonary arterial hypertension (PAH), but mechanisms that increase susceptibility are poorly understood. Laboratory studies have shown that early disruption of angiogenesis during development impairs...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Galambos, Csaba, Minic, Angela D., Bush, Douglas, Nguyen, Dominique, Dodson, Blair, Seedorf, Gregory, Abman, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972384/
https://ncbi.nlm.nih.gov/pubmed/27487163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159005
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