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Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle

Metformin-induced activation of the 5′-AMP-activated protein kinase (AMPK) has been associated with enhanced glucose uptake in skeletal muscle, but so far no direct causality has been examined. We hypothesized that an effect of in vivo metformin treatment on glucose uptake in mouse skeletal muscles...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Kristensen, Jonas Møller, Treebak, Jonas T., Schjerling, Peter, Goodyear, Laurie, Wojtaszewski, Jørgen F. P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971810/
https://ncbi.nlm.nih.gov/pubmed/24644243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00417.2013
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