A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation

Alternative polyadenylation (APA) is a general mechanism of transcript diversification in mammals, which has been recently linked to proliferative states and cancer. Different 3′ untranslated region (3′ UTR) isoforms interact with different RNA-binding proteins (RBPs), which modify the stability, tr...

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Опубликовано в: :Genome Res
Главные авторы: Gruber, Andreas J., Schmidt, Ralf, Gruber, Andreas R., Martin, Georges, Ghosh, Souvik, Belmadani, Manuel, Keller, Walter, Zavolan, Mihaela
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971764/
https://ncbi.nlm.nih.gov/pubmed/27382025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.202432.115
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