Chemically Homogenous Compounds with Antagonistic Properties at All α(1)-Adrenoceptor Subtypes but not β(1)-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

Studies proved that among all α(1)-adrenoceptors, cardiac myocytes functionally express only α(1A)- and α(1B)-subtype. Scientists indicated that α(1A)-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine the role of α(1)-adrenoceptors subtypes (i.e....

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Pytka, Karolina, Lustyk, Klaudia, Żmudzka, Elżbieta, Kotańska, Magdalena, Siwek, Agata, Zygmunt, Małgorzata, Dziedziczak, Agnieszka, Śniecikowska, Joanna, Olczyk, Adrian, Gałuszka, Adam, Śmieja, Jarosław, Waszkielewicz, Anna M., Marona, Henryk, Filipek, Barbara, Sapa, Jacek, Mogilski, Szczepan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971072/
https://ncbi.nlm.nih.gov/pubmed/27536240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00229
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