Polygenic risk of Alzheimer disease is associated with early- and late-life processes

OBJECTIVE: To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS: We computed polygenic risk scores (PGRS) using summary statistics from the Interna...

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Gepubliceerd in:Neurology
Hoofdauteurs: Mormino, Elizabeth C., Sperling, Reisa A., Holmes, Avram J., Buckner, Randy L., De Jager, Philip L., Smoller, Jordan W., Sabuncu, Mert R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Lippincott Williams & Wilkins 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970660/
https://ncbi.nlm.nih.gov/pubmed/27385740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000002922
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