Reduced Cationic Nanoparticle Cytotoxicity Based on Serum Masking of Surface Potential

Functionalization of nanoparticles with cationic moieties, such as polyethyleneimine (PEI), enhances binding to the cell membrane; however, it also disrupts the integrity of the cell’s plasma and vesicular membranes, leading to cell death. Primary fibroblasts were found to display high surface affin...

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Pubblicato in:J Biomed Nanotechnol
Autori principali: McConnell, Kellie I., Shamsudeen, Sabeel, Meraz, Ismail M., Mahadevan, Thiruvillamalai S., Ziemys, Arturas, Rees, Paul, Summers, Huw D., Serda, Rita E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970519/
https://ncbi.nlm.nih.gov/pubmed/27301181
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