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Minimax and admissible adaptive two-stage designs in phase II clinical trials
BACKGROUND: Simon’s two-stage design is the most widely implemented among multi-stage designs in phase II clinical trials to assess the activity of a new treatment in a single-arm study. In this two-stage design, the sample size from the second stage is fixed regardless of the number of responses ob...
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| Опубликовано в: : | BMC Med Res Methodol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4969653/ https://ncbi.nlm.nih.gov/pubmed/27485595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-016-0194-3 |
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