Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM(+) B Cells in The Absence of Germinal Centers

Although originally identified as a B cell differentiation factor, it is now known that mammalian interleukin-6 (IL-6) only regulates B cells committed to plasma cells in response to T-dependent (TD) antigens within germinal centers (GCs). Even though adaptive immunity is present in teleost fish, th...

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Udgivet i:Sci Rep
Main Authors: Abós, Beatriz, Wang, Tiehui, Castro, Rosario, Granja, Aitor G., Leal, Esther, Havixbeck, Jeffrey, Luque, Alfonso, Barreda, Daniel R., Secombes, Chris J., Tafalla, Carolina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969607/
https://ncbi.nlm.nih.gov/pubmed/27481356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30004
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