Protein Inhibitor of NOS1 Plays a Central Role in the Regulation of NOS1 Activity in Human Dilated Hearts

An essential factor for the production of nitric oxide by nitric oxide synthase 1 (NOS1), major modulator of cardiac function, is the cofactor tetrahydrobiopterin (BH4). BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses the formation of dihydroneo...

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Vydáno v:Sci Rep
Hlavní autoři: Roselló-Lletí, Esther, Tarazón, Estefanía, Ortega, Ana, Gil-Cayuela, Carolina, Carnicer, Ricardo, Lago, Francisca, González-Juanatey, Jose Ramón, Portolés, Manuel, Rivera, Miguel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969592/
https://ncbi.nlm.nih.gov/pubmed/27481317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30902
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