Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

The LIM-homeodomain transcription factors Lmx1a and Lmx1b play critical roles during the development of midbrain dopaminergic progenitors, but their functions in the adult brain remain poorly understood. We show here that sustained expression of Lmx1a and Lmx1b is required for the survival of adult...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Doucet-Beaupré, Hélène, Gilbert, Catherine, Profes, Marcos Schaan, Chabrat, Audrey, Pacelli, Consiglia, Giguère, Nicolas, Rioux, Véronique, Charest, Julien, Deng, Qiaolin, Laguna, Ariadna, Ericson, Johan, Perlmann, Thomas, Ang, Siew-Lan, Cicchetti, Francesca, Parent, Martin, Trudeau, Louis-Eric, Lévesque, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968767/
https://ncbi.nlm.nih.gov/pubmed/27407143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520387113
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