Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

The LIM-homeodomain transcription factors Lmx1a and Lmx1b play critical roles during the development of midbrain dopaminergic progenitors, but their functions in the adult brain remain poorly understood. We show here that sustained expression of Lmx1a and Lmx1b is required for the survival of adult...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Doucet-Beaupré, Hélène, Gilbert, Catherine, Profes, Marcos Schaan, Chabrat, Audrey, Pacelli, Consiglia, Giguère, Nicolas, Rioux, Véronique, Charest, Julien, Deng, Qiaolin, Laguna, Ariadna, Ericson, Johan, Perlmann, Thomas, Ang, Siew-Lan, Cicchetti, Francesca, Parent, Martin, Trudeau, Louis-Eric, Lévesque, Martin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968767/
https://ncbi.nlm.nih.gov/pubmed/27407143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520387113
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