Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling

Fibrillar collagen, an essential structural component of the extracellular matrix, is remarkably resistant to proteolysis, requiring specialized matrix metalloproteinases (MMPs) to initiate its remodeling. In the context of native fibrils, remodeling is poorly understood; MMPs have limited access to...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Dittmore, Andrew, Silver, Jonathan, Sarkar, Susanta K., Marmer, Barry, Goldberg, Gregory I., Neuman, Keir C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968713/
https://ncbi.nlm.nih.gov/pubmed/27402741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523228113
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