Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys

Bispecific antibodies (BsAbs) can affect multiple disease pathways, thus these types of constructs potentially provide promising approaches to improve efficacy in complex disease indications. The specific and non-specific clearance mechanisms/biology that affect monoclonal antibody (mAb) pharmacokin...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:MAbs
Main Authors: Datta-Mannan, Amita, Croy, Johnny E., Schirtzinger, Linda, Torgerson, Stacy, Breyer, Matthew, Wroblewski, Victor J.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968112/
https://ncbi.nlm.nih.gov/pubmed/27111637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1178435
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