Defective glutamate and K(+) clearance by cortical astrocytes in familial hemiplegic migraine type 2

Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial hemiplegic migraine type 2: FHM2) is caused by loss‐of‐function mutations in α(2) Na(+),K(+) ATPase (α(2) NKA), an isoform almost exclusively expressed in astrocytes in adult brain. Cortical spreading depression...

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Publicado en:EMBO Mol Med
Autores principales: Capuani, Clizia, Melone, Marcello, Tottene, Angelita, Bragina, Luca, Crivellaro, Giovanna, Santello, Mirko, Casari, Giorgio, Conti, Fiorenzo, Pietrobon, Daniela
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967947/
https://ncbi.nlm.nih.gov/pubmed/27354390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505944
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