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APP Overexpression Causes Aβ-Independent Neuronal Death through Intrinsic Apoptosis Pathway
Accumulation of amyloid-β (Aβ) peptide in the brain is a central hallmark of Alzheimer’s disease (AD) and is thought to be the cause of the observed neurodegeneration. Many animal models have been generated that overproduce Aβ yet do not exhibit clear neuronal loss, questioning this Aβ hypothesis. W...
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| Publicado no: | eNeuro |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4967816/ https://ncbi.nlm.nih.gov/pubmed/27517085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0150-16.2016 |
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