Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine

Indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells (DCs) inhibits T-cell activation and promotes T-cell differentiation into regulatory T-cells. Moreover, IDO expression promotes resistance to immunotherapies targeting immune checkpoints such as the cytotoxic T lymphocyte antigen-4 (CTL...

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Vydáno v:Case Rep Med
Hlavní autoři: Sioud, Mouldy, Nyakas, Marta, Sæbøe-Larssen, Stein, Mobergslien, Anne, Aamdal, Steinar, Kvalheim, Gunnar
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2016
Témata:
Case Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967686/
https://ncbi.nlm.nih.gov/pubmed/27504122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9639585
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