Melatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells

2-DG triggers glucose deprivation without altering other nutrients or metabolic pathways and then activates autophagy via activation of AMPK and endoplasmic reticulum (ER) stress. We investigated whether 2-DG reduced intracellular insulin increased by melatonin via autophagy/EDC3 in insulinoma INS-1...

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Bibliografische gegevens
Gepubliceerd in:Oxid Med Cell Longev
Hoofdauteurs: Kim, Han Sung, Han, Tae-Young, Yoo, Yeong-Min
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi Publishing Corporation 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967467/
https://ncbi.nlm.nih.gov/pubmed/27493704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2594703
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