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Reformulation of Fungizone by PEG-DSPE Micelles: Deaggregation and Detoxification of Amphotericin B

PURPOSE: Fungizone(®) (AmB-SD), amphotericin B solubilized by sodium deoxycholate, contains a highly aggregated form of the antifungal agent that causes dose-limiting renal toxicity. With the aim of reducing the formulation’s toxicity by co-delivering monomeric amphotericin B (AmB) and sodium supple...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharm Res
Prif Awduron: Alvarez, Celeste, Shin, Dae Hwan, Kwon, Glen S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967395/
https://ncbi.nlm.nih.gov/pubmed/27198671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-1948-7
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