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Sleep: A novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer's disease?

Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD. Moreover, insufficient sleep facilitates accumulation of amyloid-β (Aβ), potentially triggering earlier cognitive decline and...

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Detalhes bibliográficos
Publicado no:Trends Neurosci
Main Authors: Mander, Bryce A., Winer, Joseph R., Jagust, William J., Walker, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967375/
https://ncbi.nlm.nih.gov/pubmed/27325209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tins.2016.05.002
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