Exercise training reverses myocardial dysfunction induced by CaMKIIδ(C) overexpression by restoring Ca(2+) homeostasis

Several conditions of heart disease, including heart failure and diabetic cardiomyopathy, are associated with upregulation of cytosolic Ca(2+)/calmodulin-dependent protein kinase II (CaMKIIδ(C)) activity. In the heart, CaMKIIδ(C) isoform targets several proteins involved in intracellular Ca(2+) home...

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Veröffentlicht in:J Appl Physiol (1985)
Hauptverfasser: Høydal, Morten A., Stølen, Tomas O., Kettlewell, Sarah, Maier, Lars S., Brown, Joan Heller, Sowa, Tomas, Catalucci, Daniele, Condorelli, Gianluigi, Kemi, Ole J., Smith, Godfrey L., Wisløff, Ulrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967256/
https://ncbi.nlm.nih.gov/pubmed/27231311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00188.2016
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