FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness

The fibroblast growth factor receptor 2 (FGFR2) locus is consistently the top hit in genome-wide association studies for oestrogen receptor-positive (ER(+)) breast cancer. Yet, its mode of action continues to be controversial. Here, we employ a systems biology approach to demonstrate that signalling...

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Bibliographic Details
Published in:Carcinogenesis
Main Authors: Campbell, Thomas M., Castro, Mauro A.A., de Santiago, Ines, Fletcher, Michael N.C., Halim, Silvia, Prathalingam, Radhika, Ponder, Bruce A.J., Meyer, Kerstin B.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967216/
https://ncbi.nlm.nih.gov/pubmed/27236187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgw065
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