Identification of intestinal ion transport defects in microvillus inclusion disease

Loss of function mutations in the actin motor myosin Vb (Myo5b) lead to microvillus inclusion disease (MVID) and death in newborns and children. MVID results in secretory diarrhea, brush border (BB) defects, villus atrophy, and microvillus inclusions (MVIs) in enterocytes. How loss of Myo5b results...

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Publié dans:Am J Physiol Gastrointest Liver Physiol
Auteurs principaux: Kravtsov, Dmitri V., Ahsan, Md Kaimul, Kumari, Vandana, van Ijzendoorn, Sven C. D., Reyes-Mugica, Miguel, Kumar, Anoop, Gujral, Tarunmeet, Dudeja, Pradeep K., Ameen, Nadia A.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2016
Sujets:
Epithelial Biology and Secretion
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967175/
https://ncbi.nlm.nih.gov/pubmed/27229121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00041.2016
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