Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment

Microvillus inclusion disease (MVID) is an autosomal recessive condition resulting in intractable secretory diarrhea in newborns due to loss-of-function mutations in myosin Vb (Myo5b). Previous work suggested that the apical recycling endosomal (ARE) compartment is the primary location for phosphoin...

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Vydáno v:Am J Physiol Gastrointest Liver Physiol
Hlavní autoři: Kravtsov, Dmitri, Mashukova, Anastasia, Forteza, Radia, Rodriguez, Maria M., Ameen, Nadia A., Salas, Pedro J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
Témata:
Hormones and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233287/
https://ncbi.nlm.nih.gov/pubmed/25258405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00180.2014
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