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C-reactive protein exacerbates renal ischemia-reperfusion injury: are myeloid-derived suppressor cells to blame?

Myeloid-derived suppressor cells (MDSCs) are a CD11b(+)Gr1(+) population in mice that can be separated into granulocytic (g-MDSC) and monocytic (m-MDSC) subtypes based on their expression of Ly6G and Ly6C. Both MDSC subtypes are potent suppressors of T cell immunity, and their contribution has been...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Pegues, Melissa A., McWilliams, Ian L., Szalai, Alexander J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967164/
https://ncbi.nlm.nih.gov/pubmed/27053688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00107.2016
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