20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats

In male rats, androgen supplements increase 20-hydroxyeicosatetraenoic acid (20-HETE) via cytochrome P-450 (CYP)4A ω-hydroxylase and cause an increase in blood pressure (BP). In the present study, we determined the roles of 20-HETE and CYP4A2 on the elevated BP in hyperandrogenemic female rats. Chro...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Dalmasso, Carolina, Maranon, Rodrigo, Patil, Chetan, Moulana, Mohadetheh, Romero, Damian G., Reckelhoff, Jane F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967161/
https://ncbi.nlm.nih.gov/pubmed/27194719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00458.2015
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