Manganese-Stimulated Kisspeptin Is Mediated by the IGF-1/Akt/Mammalian Target of Rapamycin Pathway in the Prepubertal Female Rat

Low-dose administration of manganese chloride (MnCl(2)) causes release of hypothalamic LH-releasing hormone (LHRH) and advances puberty in rat. Recently, this element was shown to up-regulate mammalian target of rapamycin (mTOR), kisspeptin gene (KiSS-1), and LHRH gene expressions in the brain preop...

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Publicat a:Endocrinology
Autors principals: Srivastava, Vinod K., Hiney, Jill K., Dees, William L.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2016
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967113/
https://ncbi.nlm.nih.gov/pubmed/27309941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1090
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