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Whole organism lineage tracing by combinatorial and cumulative genome editing
Multicellular systems develop from single cells through distinct lineages. However, current lineage tracing approaches scale poorly to whole, complex organisms. Here we use genome editing to progressively introduce and accumulate diverse mutations in a DNA barcode over multiple rounds of cell divisi...
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| Publicado no: | Science |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4967023/ https://ncbi.nlm.nih.gov/pubmed/27229144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf7907 |
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