How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

BACKGROUND: There is currently no guidance for selecting a specific difference to be detected in a superiority trial. We explored 3 factors that in our opinion should influence the difference to be detected (type of outcome, patient age group, and presence of treatment side-effects), and 3 that shou...

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Bibliografiske detaljer
Udgivet i:BMC Med Res Methodol
Main Authors: Gayet-Ageron, Angèle, Jannot, Anne-Sophie, Agoritsas, Thomas, Rudaz, Sandrine, Combescure, Christophe, Perneger, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966776/
https://ncbi.nlm.nih.gov/pubmed/27473336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-016-0195-2
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