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Discovery and characterization of hydroxylysine in recombinant monoclonal antibodies
Tryptic peptide mapping analysis of a Chinese hamster ovary (CHO)-expressed, recombinant IgG1 monoclonal antibody revealed a previously unreported +16 Da modification. Through a combination of MS(n) experiments, and preparation and analysis of known synthetic peptides, the possibility of a sequence...
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| Veröffentlicht in: | MAbs |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966620/ https://ncbi.nlm.nih.gov/pubmed/26651858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1122148 |
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