Understanding differences between synthetic and natural antibodies can help improve antibody engineering

Synthetic libraries are a major source of human-like antibody (Ab) drug leads. To assess the similarity between natural Abs and the products of these libraries, we compared large sets of natural and synthetic Abs using “CDRs Analyzer,” a tool we introduce for structural analysis of Ab-antigen (Ag) i...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Burkovitz, Anat, Ofran, Yanay
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966605/
https://ncbi.nlm.nih.gov/pubmed/26652053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1123365
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