The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration

BACKGROUND: The most abundant cells in the extensive desmoplastic stroma of pancreatic adenocarcinomas are the pancreatic stellate cells, which interact with the carcinoma cells and strongly influence the progression of the cancer. Tumor stroma interactions induced by IL-1α/IL-1R1 signaling have bee...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Tjomsland, Vegard, Sandnes, Dagny, Pomianowska, Ewa, Cizmovic, Smiljana Torbica, Aasrum, Monica, Brusevold, Ingvild Johnsen, Christoffersen, Thoralf, Gladhaug, Ivar P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966589/
https://ncbi.nlm.nih.gov/pubmed/27473228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0400-5
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