Stability engineering of anti-EGFR scFv antibodies by rational design of a lambda-to-kappa swap of the V(L) framework using a structure-guided approach

Phage-display technology facilitates rapid selection of antigen-specific single-chain variable fragment (scFv) antibodies from large recombinant libraries. ScFv antibodies, composed of a V(H) and V(L) domain, are readily engineered into multimeric formats for the development of diagnostics and targe...

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Bibliografiska uppgifter
I publikationen:MAbs
Huvudupphovsmän: Lehmann, Andreas, Wixted, Josephine H F, Shapovalov, Maxim V, Roder, Heinrich, Dunbrack, Roland L, Robinson, Matthew K
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2015
Ämnen:
Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966335/
https://ncbi.nlm.nih.gov/pubmed/26337947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1088618
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