Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach

Artemisinin resistance in Plasmodium falciparum threatens global efforts in the elimination or eradication of malaria. Several studies have associated mutations in the PfATP6 gene in conjunction with artemisinin resistance, but the underlying molecular mechanism of the resistance remains unexplored....

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Veröffentlicht in:Sci Rep
Hauptverfasser: N., Nagasundaram, C., George Priya Doss, Chakraborty, Chiranjib, V., Karthick, D., Thirumal Kumar, V., Balaji, R., Siva, Lu, Aiping, Ge, Zhang, Zhu, Hailong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965867/
https://ncbi.nlm.nih.gov/pubmed/27471101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30106
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