Concurrent Chemotherapy of Malignant Glioma in Rats by Using Multidrug-Loaded Biodegradable Nanofibrous Membranes

Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 glio...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Tseng, Yuan-Yun, Huang, Yin-Chen, Yang, Tao-Chieh, Yang, Shun-Tai, Liu, Shou-Cheng, Chang, Tzu-Min, Kau, Yi-Chuan, Liu, Shih-Jung
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965810/
https://ncbi.nlm.nih.gov/pubmed/27471070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30630
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