Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice

Cardiac myocytes from the mdx mouse, the mouse model of Duchenne muscular dystrophy, exhibit t-tubule disarray and increased calcium sparks, but a unifying molecular mechanism has not been elucidated. Recently, improper trafficking of junctophilin (JPH)-2 on an altered microtubule network caused t-t...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Prins, Kurt W., Asp, Michelle L., Zhang, Huiliang, Wang, Wang, Metzger, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
PRE-CLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965806/
https://ncbi.nlm.nih.gov/pubmed/27482548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.02.002
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