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In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

In recent years many monoclonal antibodies (mAb) have entered the biotherapeutics market, offering new treatments for chronic and life-threatening diseases. Protein A resin captures monoclonal antibody (mAb) effectively, but the binding capacity decays over repeated purification cycles. On an indust...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Boulet-Audet, Maxime, Kazarian, Sergei G., Byrne, Bernadette
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965771/
https://ncbi.nlm.nih.gov/pubmed/27470880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30526
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