Evaluating the necessity of PCR duplicate removal from next-generation sequencing data and a comparison of approaches

BACKGROUND: Analyzing next-generation sequencing data is difficult because datasets are large, second generation sequencing platforms have high error rates, and because each position in the target genome (exome, transcriptome, etc.) is sequenced multiple times. Given these challenges, numerous bioin...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Bioinformatics
Main Authors: Ebbert, Mark T. W., Wadsworth, Mark E., Staley, Lyndsay A., Hoyt, Kaitlyn L., Pickett, Brandon, Miller, Justin, Duce, John, Kauwe, John S. K., Ridge, Perry G.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965708/
https://ncbi.nlm.nih.gov/pubmed/27454357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1097-3
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