Evaluating the necessity of PCR duplicate removal from next-generation sequencing data and a comparison of approaches

BACKGROUND: Analyzing next-generation sequencing data is difficult because datasets are large, second generation sequencing platforms have high error rates, and because each position in the target genome (exome, transcriptome, etc.) is sequenced multiple times. Given these challenges, numerous bioin...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Ebbert, Mark T. W., Wadsworth, Mark E., Staley, Lyndsay A., Hoyt, Kaitlyn L., Pickett, Brandon, Miller, Justin, Duce, John, Kauwe, John S. K., Ridge, Perry G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965708/
https://ncbi.nlm.nih.gov/pubmed/27454357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1097-3
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