The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells

The G309 allele of SNPs in the mouse double minute (MDM2) promoter locus is associated with a higher risk of cancer and proliferative vitreoretinopathy (PVR), but whether SNP G309 contributes to the pathogenesis of PVR is to date unknown. The clustered regularly interspaced short palindromic repeats...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Duan, Yajian, Ma, Gaoen, Huang, Xionggao, D'Amore, Patricia A., Zhang, Feng, Lei, Hetian
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965581/
https://ncbi.nlm.nih.gov/pubmed/27246850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729467
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