Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells

Li-Fraumeni syndrome (LFS) patients harbor germ line mutations in the TP53 gene and are at increased risk of hormone receptor-positive breast cancers. Recently, elevated levels of aromatase, the rate-limiting enzyme for estrogen biosynthesis, were found in the breast tissue of LFS patients. Although...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Subbaramaiah, Kotha, Brown, Kristy A., Zahid, Heba, Balmus, Gabriel, Weiss, Robert S., Herbert, Brittney-Shea, Dannenberg, Andrew J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2016
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965552/
https://ncbi.nlm.nih.gov/pubmed/27467582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698902
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