Conformational Response of Influenza A M2 Transmembrane Domain to Amantadine Drug Binding at Low pH (pH 5.5)

The M2 protein from influenza A plays important roles in its viral cycle. It contains a single transmembrane helix, which oligomerizes into a homotetrameric proton channel that conducts in the low-pH environment of the host-cell endosome and Golgi apparatus, leading to virion uncoating at an early s...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Georgieva, Elka R., Borbat, Peter P., Grushin, Kirill, Stoilova-McPhie, Svetla, Kulkarni, Nichita J., Liang, Zhichun, Freed, Jack H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965473/
https://ncbi.nlm.nih.gov/pubmed/27524969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00317
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