Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves

OBJECTIVE: Calcific aortic valve disease is a significant clinical problem for which the regulatory mechanisms are poorly understood. Enhanced cell-cell adhesion is a common mechanism of cellular aggregation, but its role in calcific lesion formation is not known. Cadherin-11 (Cad-11) has been assoc...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Sung, Derek C., Bowen, Caitlin J., Vaidya, Kiran A., Zhou, Jingjing, Chapurin, Nikita, Recknagel, Andrew, Zhou, Bin, Chen, Jonathan, Kotlikoff, Michael, Butcher, Jonathan T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965289/
https://ncbi.nlm.nih.gov/pubmed/27312222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307812
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