Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort

BACKGROUND: Protein tyrosine phosphatase non-receptor type 22 (PTPN22) plays an important role in immune cell function and intestinal homeostasis. The single nucleotide polymorphism (SNP) rs2476601 within the PTPN22 gene locus results in aberrant function of PTPN22 protein and protects from Crohn’s...

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Veröffentlicht in:PLoS One
Hauptverfasser: Spalinger, Marianne R., Zeitz, Jonas, Biedermann, Luc, Rossel, Jean-Benoit, Sulz, Michael C., Frei, Pascal, Scharl, Sylvie, Vavricka, Stephan R., Fried, Michael, Rogler, Gerhard, Scharl, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964985/
https://ncbi.nlm.nih.gov/pubmed/27467733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160215
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