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Optimal Hydrophobicity in ROMP-based Protein Mimics Required for siRNA Internalization

Exploring the role of polymer structure for the internalization of biologically relevant cargo, specifically siRNA, is of critical importance to the development of improved delivery reagents. Herein, we report guanidinium-rich protein transduction domain mimics (PTDMs) based on a ring-opening metath...

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Détails bibliographiques
Publié dans:Biomacromolecules
Auteurs principaux: deRonde, Brittany M., Posey, Nicholas D., Otter, Ronja, Minter, Lisa M., Tew, Gregory N.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964964/
https://ncbi.nlm.nih.gov/pubmed/27103189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.6b00138
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