MicroRNA-146a-5p Negatively Regulates Pro-Inflammatory Cytokine Secretion and Cell Activation in Lipopolysaccharide Stimulated Human Hepatic Stellate Cells through Inhibition of Toll-Like Receptor 4 Signaling Pathways

Lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) signaling pathway is demonstrated to be involved in the hepatic fibrosis. MicroRNA (miR)-146a-5p is a key regulator of the innate immune response. The functional significance of miR-146a-5p during the LPS/TLR4 mediated hepatic fibrosis process rem...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Chen, Yuhan, Zeng, Zhaochong, Shen, Xiaoyun, Wu, Zhifeng, Dong, Yinying, Cheng, Jason Chia-Hsien
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964452/
https://ncbi.nlm.nih.gov/pubmed/27399683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17071076
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